CREB and pain

Chemistry is a pain, but a pain we must go through to get rid of PAIN. Why is it discussed here? First, because doctors visit this site and we want to incite curiosity in them. Secondly, because even if you don’t get it, if you find your health professional is not with you in the matter of the reality of pain, perhaps this information will help. Don’t worry if you don’t understand it all. The general idea is what we are after, to help you appreciate what is going on in your body to cause CP. If you exert the effort to read this, you may never again feel ashamed to relate your symptoms to another person.


It is difficult to write an article which is up to date scientifically (more or less) and is also readable by the lay public. However, from the comments we receive, it would seem that the lay public is interested in such information, even if it is just to copy and hand to their doctors, in order to silence skepticism that there is something definitely wrong in their pain system.

Pain disparagement is so prevalent, as is pain trivialization, even in the medical profession (which frequently has little training in pain), that it is hoped technical articles legitimize pain as hard science, and the injured person as a real patient, who deserves the dignity of being a patient.. Such information provided to caregivers helps doctors become more curious. We attempt therefore a summary of some of the current information about CREB, although to do so requires some heavy wading through other chemicals, by name.

To speak of pain chemistry, one must have a clear understanding of the general function of kinases. This function is to activate other chemicals. By analogy, at many copy centers, one purchases a card, which then makes the copy machine run. The card will only work in the copy machine at ONE store, not in all copy machines. The cards are specific to one mechanism.

Kinases are the same way. They phosphorylate, or attach a high energy phosphate bond, to other chemicals. This allows the activated (phosphorylated) chemical to become active. The rest of the time, the chemical is inert, just sitting there like firewood stacked in the back yard. Kinases have been compared to women at a church bazaar, they are doing all the work while the men sit around and watch.

A second concept that must be learned is protein production. DNA makes up the chromosomes in our genes. The genes have been called protein factories. They produce protein by using the DNA as a template. In the first step, the DNA sequence is TRANSLATED into mRNA, which is small and can move across the nuclear membrane. A later step is TRANSLATION, where the RNA bits are connected by various tRNA