We are deliberately trying to keep these technical articles short for ease in reading, but that does not mean they are not important to you.
You may want to reread our article on NF Kappa B, NF Kappa B is itself activated by Raf-1 protein kinase. Raf-1 is the result of a gene set known as the Raf genes. They are important in development of sensory neurons.
What we are really concerned with are called the Raf serine/threonine kinases Traditionally, the RAF kinases are given alphabetic differentiation, such as “B Raf” It so happens that B Raf markedly attenuates baseline phosphorylation of Erk in neural tissues. See Zhong et al in this months Nature Neuroscience. Zhong et al also showed that “elimination of B-Raf in dorsal root ganglion (DRG) neurons …caused marked reduction in expression of the glial cell line-derived neurotrophic factor receptor Ret”
We will not cover Ret at this time, but we are certain you will be interested in anything which blocks phosphorylation (activation) or ERK in neural tissues. B-Raf is not the only Raf kinase we are intrested in, but it would be very interesting to see what RAF knockout mice would do when attemtping to make them neuropathic CP rats. Likewise, glial cell derived neurotrophic factor is not the most important growth factor in central pain, but it plays a role. You can read about the role of GDNF in the pain chemical cascade using SEARCH at this site. .