You have been reading here about inflammation in nerves being the cause of pain for years. The idea is not necessarily ours. Carl Saab was one of the first to put us on the neuroinflammation track. Now we see other authors who feel this should be regarded as fundamental.
Omoigui et al eriting in Med Hypotheses. 2007 Jan 18; “The biochemical origin of pain – Proposing a new law of pain: The origin of all pain is inflammation and the inflammatory response. Part 1 of 3 – A unifying law of pain states:
“We are proposing a unifying theory or law of pain, which states: the origin of all pain is inflammation and the inflammatory response. The biochemical mediators of inflammation include cytokines, neuropeptides, growth factors and neurotransmitters. Irrespective of the type of pain whether it is acute or chronic pain, peripheral or central pain, nociceptive or neuropathic pain, the underlying origin is inflammation and the inflammatory response”.
It is gratifying to see such a focus in the literature. One of the painonline editors was the first to publish on the idea that the common description of CP dysesthesia as “like acid under the skin” was an accurate rendering of what was going on at the nerve synapses, all the way up to the thalamus. Namely, that acid WAS being produced from cytokines and chemicals related to arachidonic acid. These chemicals are fundamental to inflammation. Painonline was the first to link the idea of ACIDIC aminio acids being behind central pain. Since then, more has been written here about the related fatty acids which participate in CP. Acidification is really the common denominator or inflammation. It took a while for this idea to sink in, but few would question it now.
Past articles here are in agreement and in one sense identical with the recently proposed hypothesis by Omogui. We hope he says it loud and clear. NEUROINFLAMMATION IS PAIN. We want to be taken seriously when we say that our burning is “like acid under the skin”. We include “like” because dysesthesia is a complex or “MIXED” sensation with pardoxical cold like elements as well as other common concommitants such as “nerve proximity”, pins and needles, and lancinating pain.