My old friend, it was nice to see you and I appreciate your invitation that we might correspond. There was of course no chance in the brief encounter to explain what has happened to me and why I was dressed so oddly, in so little clothing. You recall I mentioned Central Pain. Burning dysesthesia is what we experience to the touch of clothing. That will be a partial explanation of what must have caused you some puzzlement. It goes much deeper than that however. Knowing that you have always known me to be truthful, I decided in honor of our friendship to write this letter first, as a basis for you to decide whether you really wish to reopen a correspondence or whether you would rather not open a can of worms.
Tnank you for being a friend in my youth. The natural course of a reunion should be much joy, but Central Pain now controls me, nearly takes away my free agency. Our omniscient Heavenly Father, whom I still worship, has allowed to form in my breast a dimension of unexplainable suffering, where I myself feel possessed by an evil force, and God forgive me, He seems in my times of deepest agony, to have allowed what should have been confined to hell, to exist here on earth, here in my body.
The shocked and angry reactions of my own family, people who ought to know my character and that I would behave as well and honestly as possible show plainly enough that any correspondence will only result in major disappointment on your part. I like to be candid about these things. I might as well gross you out sooner as opposed to later. I have this uncomfortable sense of deception with every word until I explain my physical, and perhaps more importantly mental condition. Thank you for your kind encouraging attempts to suggest ways to find ways past pain. These methods are actually quantifiable by chemistry in rats, functional MRI, and the newer tensor analysis imaging, available at only two or three centers. Rats given Central Pain chew their limbs off in short dispatch (autotomy) in order to try to stop the pain. It does not work as there has been a disorder occur in the genetic protein factories. Once the genes have been locked in, in a particular cell, that cell IS the proteins it produces. For example, cells programmed to make what liver cells make, ARE liver cells. The chromosomes and genes are the same in every cell, but only stem cells can actually be redifferntiated into something new, but once they are, there is no going back. In Central Pain, the protein factories which manufacture pain chemicals create a new type of cell, which we could call a Central Pain cell.
No one has these except the lucky souls who have Central Pain. These cells become efficient factories for manufacture of pain chemicals, the very ones which operate normally. However, the sheer bulk of them overrides the control feedback and in fact, there is no evidence they are even subject to the feedback which regulates normal cells. The study of nerve cells is primarily about ion channels, which are micromachines created in the genese and embedded in the cell wall to allow charged ions to move across the cell membrane. The numbers and constitution of these channels are what programs the cell.
Most humans have excitatory and inhibitory channels to make a balance. In Central Pain, the inhibitory apparatus is eliminated. Instead new channels called Nav1.8 fetal channels pepper the membrane. These extremely sensitive channels exist only in the fetus to cause discomfort should a bad position be adopted, to prevent malformation of limbs. They make the fetus sensitive to positional pain and disappear at birth. Central Pain produces the Nav1.8 in such great numbers that the sodium flow disorders other channels, ie the calcium 2.2 voltage gated channel, which is the pain channel.
Most current pain research attempts to find a way to shut off the Ca 2.2 without shutting off the conduction system of the heart. So far they have nothing except some things to put into the spinal fluid. Pain is also about oscillations or fluctuations at given frequencies between the thalamus and cortex, which create pain signal, much the way dolphins can sense