How do you define addiction?
We have already published several articles on purine receptors but they continue to gain prominence.
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For this article, the word “Calcium” will be understood to mean the Ca2+ ion. This is soluble calcium, as opposed to the insoluble calcium in bones. Also, for brevity’s sake, neuroinflammation and hyperacidity will be used interchangeably, although the real picture is actually more complicated than that.
Toxin from the cobra known as Naja naja atra has analgesic effects. Caveat: these studies are on nociceptive (ordinary) pain models.
Some evidence seems to be mounting that some of the antieptieptic medications used for pain may have side effects on vision or cause tinnitus.
The bad guys are sometimes the good guys when nature makes them so. There had to be some reason for those hairy little creatures, the tarantulas, to be on Earth. Even the TRPV-1 receptor has been rehabilitated slightly by the discovery that it plays a vital role in preventing sepsis when humans are exposed to endotoxins (see Clark in current edition of FASEB).
A drug used for renal cell cancer turns out to block the multiple receptor tyrosine kinases prevalent in many cancer cells.
Gastrin has traditionally been associated with the stomach, but like intestinal vasoactive peptide now takes its place as a mediator of pain (itch).
A new drug, known as Q5, is generating some interesting data.