The future of medicine seems to be headed toward an understanding of channels and receptors. Nowhere is this more important than in central pain.
In a world where trendiness, fame, and fortune preoccupy the minds of so many, there is a group for which only one thing is of value, pain relief.
Inhibitors of Cox 2 (cyclooxygenase 2, related to the prostaglandin pathways) may improve the reduction in allodynia from pregabalin. We are receiving so many reports of edema, swelling, and other side effects, we are not sure pregabalin (Lyrica) will prove to be of widespread use in central pain at the required doses. However, in view of the interest over it, we mention related information. Again, always rely on your personal doctor–this site does NOT dispense medical advice–it is for educational purposes only.
We have written here about both magnetic and transcranial direct current non invasive stimulation of the motor cortex for central pain. Here is an expansion on the idea.
You already know from a prior article that injured or cut nerves leading to the brain send out many sprouts or neurites, which chemically are bad news, releasing many pain chemicals which affect nerve signal going to the brain.
You can not see pain, and therefore you probably will not see pain avoidance. Some bright investigators are changing that.
You have been reading here about inflammation in nerves being the cause of pain for years. The idea is not necessarily ours. Carl Saab was one of the first to put us on the neuroinflammation track. Now we see other authors who feel this should be regarded as fundamental.
Although this article is for the technically minded, you just as well read it, because all these terms will be common in the near future in the pain literature. Central Pain is NOT a simple disease, so the literature regarding it is not simple either. If CP could be couched in simple terms, like normal pain, the public would already know about central pain. It is tough having a highly technical disease which is also very painful. Even the rat brain is not simple, so pain from the human brain takes some attentive study to grasp.
If the scientists are correct that central pain involves an injury to the thalamus, either primarily as in stroke, or by referred exciter toxicity as in SCI, then blocking glutamate is of great importance in proventing brain injury.
We are twice as bad off as we were before spinal cord injury; or, is it a thousand times worse? It all depends.