Should Parecoxib be added to Pregabalin regimens?

Inhibitors of Cox 2 (cyclooxygenase 2, related to the prostaglandin pathways) may improve the reduction in allodynia from pregabalin. We are receiving so many reports of edema, swelling, and other side effects, we are not sure pregabalin (Lyrica) will prove to be of widespread use in central pain at the required doses. However, in view of the interest over it, we mention related information. Again, always rely on your personal doctor–this site does NOT dispense medical advice–it is for educational purposes only.

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Fasudil making an appearance

Although this article is for the technically minded, you just as well read it, because all these terms will be common in the near future in the pain literature. Central Pain is NOT a simple disease, so the literature regarding it is not simple either. If CP could be couched in simple terms, like normal pain, the public would already know about central pain. It is tough having a highly technical disease which is also very painful. Even the rat brain is not simple, so pain from the human brain takes some attentive study to grasp.

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