CGRP, calcitonin gene related peptide, has gotten lots of play because it is known to cause BDNF release in trigeminal neurons, which are thought to cause migraine. Big money is on the line.
Ziconotide is a foreign made drug with orphan status for opium refractory pain.
Contrasting with the rather frequent comment that Central Pain means God has something He wants to teach us, is the embarrassing realization that we are more ignorant than ever. A special thanks to the religiously minded who have tolerated our off the beaten path and mostly irreligious speculations.
Semaphorin 3A or its equivalent, might well prevent Central Pain in the near future if given at the time of cord injury.
A technical article, but still encouraging. We love it. We absolutely love it. We have already reviewed Frederic A. Lenz’s ideas on misallocation and central pain. Now he and his progeny at Hopkins are blasting the lid off old studies of the thalamus.
Central Pain is a one way mirror. It is not hard to see others in a certain light, impossible for them to see you. They must come close but prefer instead to stand back. Consequently, one can’t see pain if one does not have it.
Although it is the most unanswerable of questions, suffering is also one of the most compelling for those with central pain. It is just possible we will not find an answer and are not supposed to.
The National Institutes of Health has stated that since no satisfactory treatment exists for central pain, the CP subject should avoid stress wherever possible. Ever wonder what mechanism might lie behind this?
We print this article not so much because we think you will understand it, but to point out one more reason why pain scientists need MONEY for more research.