The Case for Federal Aid for Medications for Sufferers of Chronic Pain

On the one hand, we have conducted a crusade to ask doctors to stop kidding themselves that opiates stop central pain. On the other hand, we are poised on the threshold of new drugs for nerve injury pain which block the N-type Calcium channels, with prices at around $3000.00 per dose (eg. Prialt or Ziconotide), which do appear able to treat burning dysesthesia. (see below for dysesthesias which may not be burning).

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Calcium Waves and Calcium Transients

The Swedish, always very good in pain theory, have suggested that excess calcium allowed across the blood brain barrier by the action of Substance P and CGRP actually induces excessive pain synapses to form by causing glia to release factors which increase the number of synapses, which in turn increases calcium flow, etc. etc.. If true, it means the pipes for sending out pain could multiply and stay multiplied.

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