Pain echoes its way up to the brain, but when there is Central Pain, the signal is amplified at each “bounce” across a synapse. Each bounce represents acid production and action at the sodium channels to cause hypersensitivity. Other ion channels are involved also, but are not discussed here.
Full of sound and fury, signifying nothing.
Subtraction cannot equal addition. At least in life, this is true. People, especially children, do not operate like negative numbers. There is no double negative to make a positive. Pain takes away, and the reduction is accomplished. Children know they were cheated and who better to take out the anger or hatred on than the stymied parent.
Is Central Pain of any good whatsoever, to anyone?
A synapse is a connection between nerves, or possibly even a connection between a synapse and a white cell, as it now turns out.
Why don’t we just give a big bunch of money to Dr. Hulsebosch and let her work pain out? In this article we review a study of central nerve injury pain and one on peripheral (DRG) nerve injury pain.
The scientific world is getting ahead of the American Doctor’s office on pain theory. Pain chemistry is not a field in doubt, it is a field ignored. It is politically incorrect to legitimize pain patients. People who ought to be out pursuing the bad guys in swamp buggies in Florida find it more convenient to sit behind desks and arrest and imprison pain patients and their doctors.
Languages have their conventions. The meaning behind words can become obscured by convention. New studies suggest a wedding of the thalamus and cord which forces a revision in thinking about what makes something a brain structure vs. a brain visitor. One day we may describe the body in terms of interactive chemical processes. When a boy tells a girl he loves her, he may have to use three or four paragraphs of chemical reactions, before she knows if his intentions are really sincere. Long before that, we hope to have found at least one way to stop central pain. There are many.
In a study so simple it is a wonder it hasn’t been done before, some Chinese scientists in Xi’an have now shown that thermal hypersensitivity and mechanical hypersensitivity (touch) are not the same thing. Of course, the data from the survey at painonline has said this for years.
The differing types of tyrosine receptors have now been located anatomically, thanks to the sophisticated work going on at Karolinska in Sweden. We have a good relationship with Jorgen Boivie at Karolinska and he has been generous to share information. He is one of the great pain scientists of this generation.